Chemotherapy (chemo) uses strong medicines to kill cancer cells. The medicines attack and kill cells that grow quickly, like cancer cells. But some normal cells also grow quickly. Because of this, chemotherapy can harm those cells, too. This can cause side effects.
Chemotherapy can help some people with gallbladder cancer. But it’s not as helpful as other treatments may be. Chemo may be used:
After surgery (often along with radiation therapy) to kill any cancer cells that may be left, and help lower your risk that the cancer will come back
To help shrink tumors to relieve symptoms, if you're too sick to have surgery or the cancer has spread
As part of treatment for cancer that has spread, or if not all of it can be removed
Chemo medicines may be put right into your blood (into a vein) or given as pills. They then enter the bloodstream and reach all areas of your body. This is called systemic treatment.
Systemic chemotherapy doesn't always help treat gallbladder cancer. Because of this, it may be given right into the main artery going into the liver (hepatic artery). This is called hepatic artery infusion (HAI). The hepatic artery carries blood to most gallbladder tumors. Injecting the chemo here sends more medicine right to the tumor. The liver then removes most of the remaining chemo before it can reach the rest of the body. This can lessen the side effects.
Sometimes when gallbladder cancer can't be removed, HAI can help the person live longer. But more research is needed.
The chemo medicines used most often for gallbladder cancer include:
In many cases, two of these are combined as 1 treatment. This can help the chemotherapy work better.
Chemotherapy is designed to attack and kill cells that divide quickly, including cancer cells. Chemo can also affect normal cells that divide quickly. These include hair and skin cells, and bone marrow cells where new blood cells are made. The side effects of chemo are different for everyone. They depend on:
The type of chemo you're taking
How often you get chemo
How long your treatment lasts
Your age, overall health, and other factors
Side effects can include:
Mouth and throat sores
Rash on the hands and feet
Rash anywhere on your skin
Nausea and vomiting
Increased chance of infections from low levels of white blood cells
Easy bruising or bleeding from low levels of blood platelets
Tiredness from low levels of red blood cells
These side effects usually go away over time after treatment ends. There are often ways to lessen these side effects. For example, medicines can help prevent or reduce nausea and vomiting. Be sure to ask your healthcare provider what can be done to help reduce side effects.
Some medicines can have their own extra side effects. For instance, cisplatin and oxaliplatin can damage nerves. This can cause numbness, tingling, weakness, and sensitivity to cold or heat, especially in the hands and feet. This is called peripheral neuropathy. It slowly goes away in most people after treatment stops. But for some people, the effects can last a long time.
Tell your healthcare team about any side effects you have. Most side effects can be treated. In some cases, the dose of chemo may need to be adjusted. Or treatment may need to be delayed or stopped to keep side effects from getting worse.
It's important to know which chemotherapy medicines you're taking. Write down the names of your chemo medicines. Ask your healthcare team how they work and what side effects they might have.
Talk with your healthcare providers about what signs to look for and when to call them. For example, chemo can make you more likely to get infections. Make sure you know how to contact your healthcare provider, including evenings and weekends.
It may be helpful to keep a journal of your side effects. Write down physical, thinking, and emotional changes you notice. A written list will make it easier for you to remember things when you go to your appointments. It will also make it easier for you to work with your healthcare team to make a plan to manage side effects.