CYCLOPHOSPHAMIDE (sye kloe FOSS fa mide) is a chemotherapy drug. It slows the growth of cancer cells. This medicine is used to treat many types of cancer like lymphoma, myeloma, leukemia, breast cancer, and ovarian cancer, to name a few.
This drug is usually given as an injection into a vein or muscle or by infusion into a vein. It is administered in a hospital or clinic by a specially trained health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eyes, gums, or nose
signs and symptoms of heart failure like fast, irregular heartbeat, sudden weight gain; swelling of the ankles, feet, hands
signs and symptoms of infection like fever; chills; cough; sore throat; pain or trouble passing urine
signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine
signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
loss of appetite
missed menstrual periods
signs and symptoms of low red blood cells or anemia such as unusually weak or tired; feeling faint or lightheaded; falls
certain antivirals for HIV or hepatitis
certain medicines for blood pressure, heart disease, irregular heart beat
certain medicines that treat or prevent blood clots like warfarin
certain other medicines for cancer
medicines that relax muscles for surgery
medicines to increase blood counts
It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.
This drug is given in a hospital or clinic and will not be stored at home.
They need to know if you have any of these conditions:
history of irregular heartbeat
low blood counts, like white cells, platelets, or red blood cells
recent or ongoing radiation therapy
scarring or thickening of the lungs
trouble passing urine
an unusual or allergic reaction to cyclophosphamide, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Your condition will be monitored carefully while you are receiving this medicine.
You may need blood work done while you are taking this medicine.
Drink water or other fluids as directed. Urinate often, even at night.
Some products may contain alcohol. Ask your health care professional if this medicine contains alcohol. Be sure to tell all health care professionals you are taking this medicine. Certain medicines, like metronidazole and disulfiram, can cause an unpleasant reaction when taken with alcohol. The reaction includes flushing, headache, nausea, vomiting, sweating, and increased thirst. The reaction can last from 30 minutes to several hours.
Do not become pregnant while taking this medicine or for 1 year after stopping it. Women should inform their health care professional if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 4 months after stopping it. There is potential for serious side effects to an unborn child. Talk to your health care professional for more information.
Do not breast-feed an infant while taking this medicine or for 1 week after stopping it.
This medicine has caused ovarian failure in some women. This medicine may make it more difficult to get pregnant. Talk to your health care professional if you are concerned about your fertility.
This medicine has caused decreased sperm counts in some men. This may make it more difficult to father a child. Talk to your health care professional if you are concerned about your fertility.
Call your health care professional for advice if you get a fever, chills, or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This medicine decreases your body's ability to fight infections. Try to avoid being around people who are sick.
Avoid taking medicines that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your health care professional. These medicines may hide a fever.
Talk to your health care professional about your risk of cancer. You may be more at risk for certain types of cancer if you take this medicine.
If you are going to need surgery or other procedure, tell your health care professional that you are using this medicine.
Be careful brushing or flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.