BOSENTAN (boe SEN tan) is used to treat a serious heart and lung disorder called pulmonary hypertension. This medicine may help to increase your ability to exercise and improve your breathing.
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take this medicine with or without food. If it upsets your stomach, take it with food. Take your doses at regular intervals. Do not take more often than directed. Do not stop taking except on your doctor's advice.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 3 years, precautions do apply.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
rash, fever, and swollen lymph nodes
signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired
swelling of the ankles, feet, hands
Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):
Do not take this medicine with any of the following medications:
female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
This medicine may also interact with the following medications:
certain medicines for cholesterol like atorvastatin, lovastatin, and simvastatin
certain medicines for fungal infections like fluconazole, ketoconazole, and itraconazole
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
They need to know if you have any of these conditions:
an unusual or allergic reaction to bosentan, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Tell your doctor or healthcare provider if your symptoms do not start to get better or if they get worse.
Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your healthcare provider or pharmacist for more information.
This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your healthcare provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.
This medicine has caused reduced sperm counts in some men. This may interfere with the ability to father a child. You should talk to your doctor or healthcare provider if you are concerned about your fertility.
You may need blood work done while you are taking this medicine.